Round of 32, 1st leg : 16-17 February 2012
| Rubin |  | 0 - 1 |  | Olympiacos |
| Braga |  | 0 - 2 |  | Beşiktaş |
| Lok. Moskva |  | 2 - 1 |  | Athletic |
| Salzburg |  | 0 - 4 |  | Metalist |
| Ajax |  | 0 - 2 |  | Man. United |
| Plzeň |  | 1 -1 |  | Schalke |
| AZ |  | 1 - 0 |  | Anderlecht |
| Lazio |  | 1 - 3 |  | Atlético |
| Legia |  | 2 - 2 |  | Sporting |
| Steaua |  | 0 - 1 |  | Twente |
| Wisła |  | 1 - 1 |  | Standard Liège |
| Udinese |  | 0 - 0 |  | PAOK |
| Trabzonspor |  | 1 - 2 |  | PSV |
| Hannover |  | 2 - 1 |  | Club Brugge |
| Porto |  | 1 - 2 |  | Man. City |
| Stoke |  | 0 - 1 |  | Valencia |
Round of 32, 2nd leg : 23-24 February 2012
| Man. City | | 4 - 0 | | Porto |
| Valencia | | 1 - 0 | | Stoke |
| Athletic | | 1 - 0 | | Lokomotiv Moskva |
| Twente | | 1 - 0 | | Steaua |
| PAOK | | 0 - 3 | | Udinese |
| PSV | | 4 - 1 | | Trabzonspor |
| Club Brugge | | 0 - 1 | | Hannover |
| Standard Liège | | 0 - 0 | | Wisła |
| Beşiktaş | | 0 - 1 | | Braga |
| Man. United | | 1 - 2 | | Ajax |
| Sporting | | 1 - 0 | | Legia |
| Schalke | | 3 - 1 | | Plzeň |
| Metalist | | 4 - 1 | | Salzburg |
| Olympiacos | | 1 - 0 | | Rubin |
| Anderlecht | | 0 - 1 | | AZ |
| Atlético | | 1 - 0 | | Lazio |
* Updated: 24/02/2012 06:00 WIB
** Jadwal Waktu Indonesia Bagian Barat
*** Waktu GMT -6
