Babak 16, leg 1 : 9 Maret 2012
| 9 Maret 2012 | ||||
| Metalist |  | 0 - 1 |  | Olympiacos David Fuster 50' |
| 9 Maret 2012 | ||||
| Sporting Xandão 51' |  | 1 - 0 |  | Man. City |
| 9 Maret 2012 | ||||
| Twente De Jong 61'(P) |  | 1 - 0 |  | Schalke |
| 9 Maret 2012 | ||||
| Standard Liège Buyens 27' Tchite 30' |  | 2 - 2 |  | Hannover Stindl 22'(P) Diouf 56' |
| 9 Maret 2012 | ||||
| Valencia Víctor Ruiz 11' Manolev 13'(o.g.) Soldado 43'(P) Piatti 56' |  | 4 - 2 |  | PSV |
| 9 Maret 2012 | ||||
| AZ Alkmaar Martens 63' Falkenburg 84' |  | 2 - 0 |  | Udinese |
| 9 Maret 2012 | ||||
| Atlético Salvio 24', 27' Adrián López 37' |  | 3 - 1 |  | Beşiktaş Simão 53' |
| 9 Maret 2012 | ||||
| Man. United Rooney 22', 90'+2(P) |  | 2 - 3 |  | Athletic Llorente 44' De Marcos 71' Muniain 90' |
Babak 16, leg 2 : 16 Maret 2012
| 16 Maret 2012 | ||||
| Olympiacos Marcano 15' | | 1 - 2 AGG: 2-2 Metalist Win Gol Away | | Metalist Villagra 81' Dević 86' |
| 16 Maret 2012 | ||||
| Man. City Agüero 60', 82' Balotelli 75'(P) | | 3 - 2 AGG: 3-3 Sporting win Gol Away | | Sporting Fernández 33' Van Wolfswinkel 40' |
| 16 Maret 2012 | ||||
| Schalke Huntelaar 29',56'(P),81' Jones 71' | | 4 - 1 AGG: 4-2 | | Twente Janssen 14' |
| 16 Maret 2012 | ||||
| Hannover Abdellaoue 4' Kanu 21'(o.g.), 73'(o.g.) Pinto 90'+3 | | 4 - 0 AGG: 6-2 | | Standard Liège |
| 16 Maret 2012 | ||||
| PSV Toivonen 64' | | 1- 1 AGG: 3-5 | | Valencia Rami 47' |
| 16 Maret 2012 | ||||
| Udinese Di Natale 3'(P), 15' | | 2 - 1 AGG: 2-3 | | AZ Alkmaar Falkenburg 31' |
| 16 Maret 2012 | ||||
| Beşiktaş | | 0 - 3 AGG: 1-6 | | Atlético Adrián López 26' Falcao 83' Salvio 90'+3 |
| 16 Maret 2012 | ||||
| Athletic Llorente 23' De Marcos 65' | | 2 -1 AGG: 5-3 | | Man. United Rooney 80' |
